Optimal cross-over designs under a mixed effects model
نویسندگان
چکیده
For a general cross-over design, combined intra-inter unit reduced normal equations for estimating linear functions of direct and residual effects are obtained under a mixed effects, non-additive model. The unit effects are considered as random and the model allows for possible interactions among treatments applied at successive periods. Several existing families of designs which are optimal under a fixed effects model are shown to be so under the considered mixed model as well.
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تاریخ انتشار 2003